Greedy Insider
Upstream Bio, Inc. (UPB) Insider Trades and Scores
Upstream Bio, Inc. (UPB) insider trades: since Mar 16, 2026, Greedy Insider recorded 0 open-market buys and 15 sales on Form 4 from 5 insiders. The strongest recent filing scored 84 (Strong).
Who bought and who sold
Across the last 15 scoreable Form 4 transactions in UPB, 0 were open-market purchases and 15 were sales. The table lists the most recent filings with each one's Greediness Score, so the structurally unusual trades are easy to spot first.
| Insider | Role | Type | Shares | Date | Score | ||
|---|---|---|---|---|---|---|---|
| Deykin Aaron | Chief Medical Officer | Sell | 895.0 | 4913.55 | 2026-09-16 | 80 | View |
| GRAY MICHAEL | CFO and COO | Sell | 853.0 | 4682.97 | 2026-09-16 | 80 | View |
| Sutherland Everett Rand | CEO | Sell | 2095.0 | 11501.55 | 2026-09-16 | 80 | View |
| Houghton Adam | Chief Business Officer | Sell | 700.0 | 3843.0 | 2026-09-16 | 80 | View |
| Ambrose Allison | General Counsel | Sell | 485.0 | 2662.65 | 2026-09-16 | 68 | View |
| GRAY MICHAEL | CFO and COO | Sell | 853.0 | 5203.3 | 2026-06-16 | 81 | View |
| Sutherland Everett Rand | CEO | Sell | 2095.0 | 12779.5 | 2026-06-16 | 81 | View |
| Houghton Adam | Chief Business Officer | Sell | 700.0 | 4270.0 | 2026-06-16 | 81 | View |
| Deykin Aaron | Chief Medical Officer | Sell | 895.0 | 5459.5 | 2026-06-16 | 81 | View |
| Ambrose Allison | General Counsel | Sell | 477.0 | 2909.7 | 2026-06-16 | 69 | View |
The strongest recent filing
GRAY MICHAEL (CFO and COO) sold 852 shares of Upstream Bio, Inc. on Mar 16, 2026, a filing that scored 84 (Strong). It scored Strong because a senior insider was trading and it was direct personal ownership. The score describes the filing, not future returns. This is not investment advice.
Cluster activity
A cluster buy is present: 5 insiders (GRAY MICHAEL, Deykin Aaron, Sutherland Everett Rand, Ambrose Allison) traded UPB the same direction within a 7-day window. Shared conviction is a stronger structural signal than a lone trade.
How this compares with Upstream Bio, Inc.'s own history
Open-market buys make up 0% of the 15 scoreable UPB transactions on record between Mar 16, 2026 and Sep 16, 2026. Comparing a filing with the company's own buy/sell mix is how you tell a routine disposal from an unusual accumulation.
Methodology and sources
Scores come from six published, user-adjustable factors (insider role, cluster activity, trade size versus the insider's own history, position impact, filing urgency, and direct versus indirect ownership). The score describes the filing, not future returns. This is not investment advice.
Key facts
- Scoreable Form 4 transactions on record: 15
- Open-market buys: 0
- Sales: 15
- Distinct insiders: 5
- Strongest recent Greediness Score: 84 (Strong)
Primary sources
Related
- Strongest filing
- UPB in the live feed
- How the Greediness Score works
- What is a cluster buy?
- Form 4 transaction codes
The score describes the filing, not future returns. This is not investment advice.